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Exam 13: The Genetic Control of Development

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Question 1

Multiple Choice

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The homeodomain encodes:

A) a helix-turn-helix motif.
B) an ATP-binding domain.
C) a leucine zipper.
D) a zinc-finger.
E) a protease.

F) A) and D)
G) C) and E)

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Question 2

Multiple Choice

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The class of genes that affect patterning within each segment is the:

A) maternal-effect genes.
B) gap genes.
C) pair-rule genes.
D) segment polarity genes.
E) Hox genes.

F) C) and D)
G) A) and B)

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Question 3

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Shown below is a list of molecules that function in Drosophila development (a-g)and a list of possible distribution patterns (1-5).On the line following each distribution pattern,write the letter(s)of the molecule(s)showing that type of distribution pattern. a)toll transmembrane receptor b)hunchback protein c)activated SPZ ligand d)inactive DL protein e)active DL protein f)NOS protein g)Bicoid protein 1)Highest gradient is in the anterior end of the embryo.__________ 2)Highest gradient is in the posterior end of the embryo.__________ 3)Highest gradient is at the ventral midpoint of the embryo.__________ 4)This is distributed throughout the oocyte/embryo.__________ 5)This is present uniformly in the oocyte plasma membrane.__________

Shown below is a list of molecules that function in Drosophila development (a–g) and a list of possible distribution patterns (1–5). Match the molecule(s) showing that type of distribution pattern.

The maternal-effect Bicoid gene codes for:

A scientist working in a Drosophila lab locates a mutation in an organism that caused antenna to be transformed into legs.He determines that this is a homeotic transformation.Do you agree?

In Drosophila melanogaster,Hox genes are:

In Drosophila,the vast majority of A-P axis genes that contribute to pattern formation encode:

Why would animals as diverse as mice,humans,and Drosophila have maintained nearly identical Hox genes?

Genes with products provided by the female to the egg are called:

The products of the gene let-7 is a well-known:

The formation of stripe 2 in a Drosophila embryo is controlled by the binding of four transcription factors to the eve stripe 2 cis-acting regulatory element.This includes:

Establishment of the dorsal-ventral axis of the Drosophila embryo:

In the nematode worm,C.elegans,embryonic development is controlled largely by controlling _______________.

The early Drosophila embryo has multiple nuclei within a single cytoplasm and is considered a:

Shown below is a list of gene classes that play a role in Drosophila development. $\quad$$\quad$$\quad$$\quad$$\quad$ homeotic genes $\quad$$\quad$$\quad$$\quad$$\quad$ gap genes $\quad$$\quad$$\quad$$\quad$$\quad$ segment-polarity genes $\quad$$\quad$$\quad$$\quad$$\quad$ maternal-effect genes $\quad$$\quad$$\quad$$\quad$$\quad$ pair-rule genes (i)Describe the role of each class of genes and the impact that a mutation in the class has on Drosophila development. (ii)The different classes of genes function at different times during Drosophila development.Put the gene classes in order,from earliest to latest.

Drosophila melanogaster development proceeds in which of the following stages?

There are ______ Hox genes in Drosophila melanogaster.

What is the single most important early feature that controls spatial expression of developmental genes in the Drosophila embryo?

The class of genes required that act at a double-segment periodicity is the: